Commander Chris Hadfield has built up hundreds of thousands of followers onTwitter by posting photographs of the earth from space.
But the music video could prove to be his most popular contribution yet.
The Canadian, who will fly home today as his five-month mission comes to an end, is shown playing an acoustic guitar and singing Bowie's classic Space Oddity.
Bowie replied: "Hallo Spaceboy."
Before going into orbit, Hadfield said playing music was important in taking care of the "psychological side" of living in space.